Methanol → (2-Bromo-5-fluorophenyl)methanamine

HRID 956615Notes

Reaction equation

HRID 956615 reaction equation
[BH4-:11].[Br:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][c:7]([F:10])[cH:8][cH:9]1.[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[CH3:20][OH:21].[CH3:27][CH2:28][O:29][C:30]([CH3:31])=[O:32].[F:13][C:14]([F:15])([F:16])[C:17]([OH:18])=[O:19].[Na+:12]>>[Br:1][c:2]1[c:3]([CH2:4][NH2:5])[cH:6][c:7]([F:10])[cH:8][cH:9]1

Participants

8

Reactant 7

HCID 887MethanolHCID 923Sodium ionHCID 6422Trifluoroacetic acidHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28123BorohydrideHCID 936542-Bromo-5-fluorobenzonitrile

Product 1

HCID 2773357(2-Bromo-5-fluorophenyl)methanamine

Sources & evidence

ORD record
ord-dc640ddb6aca40c28ede6b479be4b4af
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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