Ammonium → 1-(4-Benzyl-4-hydroxy-piperidin-1-yl)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propan-2-one

HRID 958817Notes

Reaction equation

HRID 958817 reaction equation
[C:1]([Cl:2])(=[O:3])[C:4]([Cl:5])=[O:6].[CH2:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[C:18]1([OH:42])[CH2:19][CH2:20][N:21]([CH2:24][CH:25]([CH2:26][c:27]2[cH:28][cH:29][c:30]([O:33][Si:34]([CH3:35])([CH3:36])[C:37]([CH3:38])([CH3:39])[CH3:40])[cH:31][cH:32]2)[OH:41])[CH2:22][CH2:23]1.[CH3:43][CH2:44][N:45]([CH2:46][CH3:47])[CH2:48][CH3:49].[CH3:7][S:8](=[O:9])[CH3:10].[Cl-:50].[Cl:52][CH2:53][Cl:54].[NH4+:51]>>[CH2:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[C:18]1([OH:42])[CH2:19][CH2:20][N:21]([CH2:24][C:25]([CH2:26][c:27]2[cH:28][cH:29][c:30]([O:33][Si:34]([CH3:35])([CH3:36])[C:37]([CH3:38])([CH3:39])[CH3:40])[cH:31][cH:32]2)=[O:41])[CH2:22][CH2:23]1

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 679Dimethyl SulfoxideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 70045791(RS)-4-Benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-propyl}-piperidin-4-ol

Product 1

HCID 700483361-(4-Benzyl-4-hydroxy-piperidin-1-yl)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propan-2-one

Sources & evidence

ORD record
ord-159cb1f224dc45feafe4f3ee3561e2e9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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