Hydrochloric Acid → Tert-butyl 2-(aminocarbonyl)-4-fluorobenzylcarbamate

HRID 959212Notes

Reaction equation

HRID 959212 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][c:10]1[c:11]([C:12](=[O:13])[OH:14])[cH:15][c:16]([F:19])[cH:17][cH:18]1.[CH3:21][N:22]([CH3:23])[CH2:24][CH2:25][CH2:26][N:27]=[C:28]=[N:29][CH2:30][CH3:31].[ClH:20].[O:42]=[CH:43][N:44]([CH3:45])[CH3:46].[OH:32][n:33]1[c:34]2[n:35][cH:36][cH:37][cH:38][c:39]2[n:40][n:41]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][c:10]1[c:11]([C:12](=[O:13])[NH2:22])[cH:15][c:16]([F:19])[cH:17][cH:18]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 181649HOAtHCID 110654742-[[(tert-Butoxycarbonyl)amino]methyl]-5-fluorobenzoic acid

Product 1

HCID 59645228Tert-butyl 2-(aminocarbonyl)-4-fluorobenzylcarbamate

Sources & evidence

ORD record
ord-5f679262d5184c8fb6611ab2c110cac7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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