Dimethylformamide → N-{6-methyl-4'-[(4-methylpiperazin-1-yl)carbonyl]-1,1'-biphenyl-3-yl}2-pyrrolidin-1-ylisonicotinamide
Reaction equation
[CH3:1][c:2]1[c:3](-[c:22]2[cH:23][cH:24][c:25]([C:28](=[O:29])[OH:30])[cH:26][cH:27]2)[cH:4][c:5]([NH:8][C:9]([c:10]2[cH:11][c:12]([N:16]3[CH2:17][CH2:18][CH2:19][CH2:20]3)[n:13][cH:14][cH:15]2)=[O:21])[cH:6][cH:7]1.[CH3:74][N:75]1[CH2:76][CH2:77][NH:78][CH2:79][CH2:80]1.[CH:65]([N:66]([CH2:67][CH3:68])[CH:69]([CH3:70])[CH3:71])([CH3:72])[CH3:73].[O:81]=[CH:82][N:83]([CH3:84])[CH3:85].[OH:55][n:56]1[c:57]2[c:58]([cH:59][cH:60][cH:61][cH:62]2)[n:63][n:64]1.[P-:31]([F:32])([F:33])([F:34])([F:35])([F:36])[F:37].[n:38]1([O:39][C:40]([N:41]([CH3:42])[CH3:43])=[N+:44]([CH3:45])[CH3:46])[c:47]2[n:48][cH:49][cH:50][cH:51][c:52]2[n:53][n:54]1>>[CH3:1][c:2]1[c:3](-[c:22]2[cH:23][cH:24][c:25]([C:28](=[O:30])[N:78]3[CH2:77][CH2:76][N:75]([CH3:74])[CH2:80][CH2:79]3)[cH:26][cH:27]2)[cH:4][c:5]([NH:8][C:9]([c:10]2[cH:11][c:12]([N:16]3[CH2:17][CH2:18][CH2:19][CH2:20]3)[n:13][cH:14][cH:15]2)=[O:21])[cH:6][cH:7]1Participants
8
Reactant 7
HCID 6228Dimethylformamide
HCID 9886Hexafluorophosphate
HCID 531671-Methylpiperazine
HCID 757711-Hydroxybenzotriazole
HCID 81531Diisopropylethylamine
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 113501482'-Methyl-5'-[(2-pyrrolidin-1-ylisonicotinoyl)amino]-1,1'-biphenyl-4-carboxylic acidProduct 1
Sources & evidence
- ORD record
- ord-cc895560e85645ab8614e943fb5c5e02
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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