Dichloromethane → Rac-(2r,3r,4r,5r)-5-(3-chloro-phenyl)-4-(4-chloro-phenyl)-4-cyano-3-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid(3-hydroxy-propyl)-amide
Reaction equation
[CH:66]([N:67]([CH2:68][CH3:69])[CH:70]([CH3:71])[CH3:72])([CH3:73])[CH3:74].[Cl:75][CH2:76][Cl:77].[Cl:8][c:9]1[cH:10][c:11]([CH:15]2[C:16]([C:28]#[N:29])([c:30]3[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]3)[CH:17]([CH2:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH:18]([C:20](=[O:21])[OH:22])[NH:19]2)[cH:12][cH:13][cH:14]1.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[NH2:37][CH2:38][CH2:39][CH2:40][OH:41].[P-:42]([F:43])([F:44])([F:45])([F:46])([F:47])[F:48].[n:49]1([O:50][C:51]([N:52]([CH3:53])[CH3:54])=[N+:55]([CH3:56])[CH3:57])[c:58]2[n:59][cH:60][cH:61][cH:62][c:63]2[n:64][n:65]1>>[Cl:8][c:9]1[cH:10][c:11]([CH:15]2[C:16]([C:28]#[N:29])([c:30]3[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]3)[CH:17]([CH2:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH:18]([C:20](=[O:22])[NH:37][CH2:38][CH2:39][CH2:40][OH:41])[NH:19]2)[cH:12][cH:13][cH:14]1Participants
8
Reactant 7
HCID 6344Dichloromethane
HCID 6422Trifluoroacetic acid
HCID 90863-Amino-1-propanol
HCID 9886Hexafluorophosphate
HCID 81531Diisopropylethylamine
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 672968115-(3-Chlorophenyl)-4-(4-chlorophenyl)-4-cyano-3-(2,2-dimethylpropyl)pyrrolidine-2-carboxylic acidProduct 1
Sources & evidence
- ORD record
- ord-f8237daf3b63415d8246dea699dd1297
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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