Benzaldehyde → 2-Chloro-α-phenyl-6-(trifluoromethyl)-3-pyridinemethanol
Reaction equation
[CH:1]([N-:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[CH:20](=[O:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[Cl:9][c:10]1[n:11][c:12]([C:16]([F:17])([F:18])[F:19])[cH:13][cH:14][cH:15]1.[Li+:8].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1.[OH2:28]>>[Cl:9][c:10]1[n:11][c:12]([C:16]([F:17])([F:18])[F:19])[cH:13][cH:14][c:15]1[CH:20]([OH:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1Participants
7
Sources & evidence
- ORD record
- ord-7caad2169ff24936bbd81e734f615842
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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