Dimethylformamide → [1-(2-Chloro-benzenesulfonyl)-piperidin-3-yl]-(2-m-tolyl-pyrrolidin-1-yl)-methanone
Reaction equation
[CH3:21][c:22]1[cH:23][c:24]([CH:28]2[NH:29][CH2:30][CH2:31][CH2:32]2)[cH:25][cH:26][cH:27]1.[CH:33]([N:34]([CH2:35][CH3:36])[CH:37]([CH3:38])[CH3:39])([CH3:40])[CH3:41].[Cl:1][c:2]1[c:3]([S:8](=[O:9])(=[O:10])[N:11]2[CH2:12][CH:13]([C:17](=[O:18])[O-:19])[CH2:14][CH2:15][CH2:16]2)[cH:4][cH:5][cH:6][cH:7]1.[Cl:71][CH2:72][Cl:73].[Li+:20].[O:66]=[CH:67][N:68]([CH3:69])[CH3:70].[P-:42]([F:43])([F:44])([F:45])([F:46])([F:47])[F:48].[n:49]1([O:50][C:51]([N:52]([CH3:53])[CH3:54])=[N+:55]([CH3:56])[CH3:57])[c:58]2[n:59][cH:60][cH:61][cH:62][c:63]2[n:64][n:65]1>>[Cl:1][c:2]1[c:3]([S:8](=[O:9])(=[O:10])[N:11]2[CH2:12][CH:13]([C:17](=[O:19])[N:29]3[CH:28]([c:24]4[cH:23][c:22]([CH3:21])[cH:27][cH:26][cH:25]4)[CH2:32][CH2:31][CH2:30]3)[CH2:14][CH2:15][CH2:16]2)[cH:4][cH:5][cH:6][cH:7]1Participants
9
Reactant 8
HCID 6228Dimethylformamide
HCID 6344Dichloromethane
HCID 9886Hexafluorophosphate
HCID 28486Lithium ion
HCID 81531Diisopropylethylamine
HCID 35440982-(3-Methylphenyl)pyrrolidine
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 578223011-(2-Chlorophenyl)sulfonylpiperidine-3-carboxylateProduct 1
Sources & evidence
- ORD record
- ord-92b927ecb51548e7bd86e486ce08a4ec
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
Loading…