Hydrochloric Acid → HCID 86752748, compound

HRID 963261Notes

Reaction equation

HRID 963261 reaction equation
Cl.Cl.[CH3:3][C@@H:4]([N:17]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=1)[C:18]([CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1)=[O:19])[CH2:5][N:6]1[CH2:11][CH:10]=[C:9]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)[CH2:8][CH2:7]1.ClC1C=CC=C(C(OO)=[O:40])C=1.Cl>>[CH3:3][C@@H:4]([N:17]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=1)[C:18]([CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1)=[O:19])[CH2:5][N:6]1[CH2:7][CH:8]=[C:9]([C:12]2[S:13](=[O:40])[CH:14]=[CH:15][CH:16]=2)[CH2:10][CH2:11]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 70297m-Chloroperbenzoic acidHCID 86752749HCID 86752749, compound

Product 1

HCID 86752748HCID 86752748, compoundYield 45.7%

Procedure

The title compound was prepared from cyclohexanecarboxylic acid (R)-[1-methyl-2-(4-thiophen-2-yl-3,6-dihydro-2H-pyrid-1-yl)-ethyl]-(pyrid-2-yl)-amide dihydrochloride (1.5 g, 3.6 mmol) and meta-chloroperbenzoic acid (0.632 g, 3.6 mmol) to yield 0.7 g of the title compound as the 1.8 hydrochloride, m.p. 109°-11° C.

Sources & evidence

ORD record
ord-b8ff262fc8bd48c08bcd0d192b3c0ef1
Source dataset
uspto-grants-1998_06
Patent number
US05763460

Reaction notes

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