Piperidine → HCID 23202566, compound

HRID 963358Notes

Reaction equation

HRID 963358 reaction equation
ClCCCCC=O.C([NH:11][C:12]1[C:17]([Cl:18])=[CH:16][C:15]([C:19](=[O:25])[CH2:20][CH2:21][CH2:22][CH2:23]Cl)=[C:14]([O:26][CH2:27][C:28]2[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[C:30]([O:36][CH3:37])[CH:29]=2)[CH:13]=1)(=O)C.N1CCCCC1.[NH:44]1[CH2:50][CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]1>>[NH2:11][C:12]1[C:17]([Cl:18])=[CH:16][C:15]([C:19](=[O:25])[CH2:20][CH2:21][CH2:22][CH2:23][N:44]2[CH2:50][CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]2)=[C:14]([O:26][CH2:27][C:28]2[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[C:30]([O:36][CH3:37])[CH:29]=2)[CH:13]=1

Participants

5

Reactant 4

HCID 8082PiperidineHCID 8119AzepaneHCID 6430485-chloropentanalHCID 19081830HCID 19081830, compound

Product 1

HCID 23202566HCID 23202566, compound

Procedure

Proceeding as in Example 4, Step (c), but replacing 1-4-acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one with 1-[4-acetylamino-5-chloro-2-(3,5-dimethoxybenzyloxy) phenyl]-5-chloropentan-1-one and piperidine with azacycloheptane, gave 1-[4-amino-5-chloro-2-(3,5-dimethoxybenzyloxy) phenyl]-5-(azacyclohept-1-yl)pentan-1-one, m.p. 137°-139° C.

Sources & evidence

ORD record
ord-9b393bdc072940b7893dc2b94ba0a0d6
Source dataset
uspto-grants-1998_06
Patent number
US05763458

Reaction notes

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