Oxalyl chloride → HCID 21833062, compound

HRID 965169Notes

Reaction equation

HRID 965169 reaction equation
[C:1]([C:4]1[O:5][C:6]2[C:7](=[C:9]([C:15]([OH:17])=O)[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH:8]=1)(=[O:3])[CH3:2].C(Cl)(=O)C([Cl:21])=O>ClCCl.CN(C)C=O>[C:1]([C:4]1[O:5][C:6]2[C:7](=[C:9]([C:15]([Cl:21])=[O:17])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH:8]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 218330412-Acetyl-7-methoxy-4-benzofurancarboxylic acid

Product 1

HCID 21833062HCID 21833062, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

Intermediate 3 (0.12 g) was suspended in anhydrous dichloromethane (4 ml) at room temperature under nitrogen and oxalyl chloride (0.1 ml) added followed by 3 drops of N,N-dimethylformamide. Evaporation in vacuo after 2 hours afforded the title compound as a yellow solid (~0.5 g).

Workup

  1. customEvaporation in vacuo after 2 hours

Sources & evidence

ORD record
ord-27c7595eebb04e1bb08e25e49e1c0f9d
Source dataset
uspto-grants-1998_06
Patent number
US05773467

Reaction notes

Loading…