Sodium Iodide → 1-(2-(4-(4-Fluorobenzoyl)-1-piperidinyl)-1-ethyl)-1H-indol-2,3-dione monohydrochloride

HRID 965303Notes

Reaction equation

HRID 965303 reaction equation
[Cl:1][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[C:5]1=[O:14].C1(C)C=CC(S(O)(=O)=O)=CC=1.[F:26][C:27]1[CH:40]=[CH:39][C:30]([C:31](N2CCCCC2)=[O:32])=[CH:29][CH:28]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+].[CH3:49][N:50]1[CH2:54][CH2:53][CH2:52][C:51]1=O>>[ClH:1].[F:26][C:27]1[CH:28]=[CH:29][C:30]([C:31]([CH:53]2[CH2:54][CH2:49][N:50]([CH2:2][CH2:3][N:4]3[C:12]4[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=4)[C:6](=[O:13])[C:5]3=[O:14])[CH2:51][CH2:52]2)=[O:32])=[CH:39][CH:40]=1

Participants

6

Reactant 5

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 1896570HCID 1896570, compoundHCID 187806554-Fluorobenzoylpiperidine para toluenesulfonate

Product 1

HCID 699757301-(2-(4-(4-Fluorobenzoyl)-1-piperidinyl)-1-ethyl)-1H-indol-2,3-dione monohydrochloride

Procedure

Prepared from 1-(2-chloroethyl)-1H-indol-2,3-dione and 4-fluorobenzoyl piperidine para toluenesulfonate and potassium carbonate and sodium iodide in N-methylpyrrolidinone.

Sources & evidence

ORD record
ord-73950ecb331248bd91eedf5e462a6561
Source dataset
uspto-grants-1998_06
Patent number
US05773448

Reaction notes

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