Piperidine → HCID 178483627, compound

HRID 967180Notes

Reaction equation

HRID 967180 reaction equation
Cl[CH2:2]/[CH:3]=[CH:4]/[C@H:5]1[CH2:10][CH2:9][C@H:8]([CH2:11][CH2:12][N:13]([CH3:27])[S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:7][CH2:6]1.[NH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>CN(C)C(=O)C>[CH3:27][N:13]([CH2:12][CH2:11][C@H:8]1[CH2:9][CH2:10][C@H:5](/[CH:4]=[CH:3]/[CH2:2][N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH2:6][CH2:7]1)[S:14]([C:17]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=1)(=[O:16])=[O:15]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 178483624HCID 178483624, compound

Product 1

HCID 178483627HCID 178483627, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In analogy to the method described in example 12.1, trans-N-{2-[4-(3-chloro-(E)-propenyl)-cyclohexyl]-ethyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide was reacted with piperidine in N,N-dimethylacetamide at room temperature to yield trans-N-methyl-N-{2-[4-(3-piperidin-1-yl-(E)-propenyl)-cyclohexyl]-ethyl}-4-trifluoromethyl-benzenesulfonamide as colorless viscous oil, MS: 473 (MH+).

Sources & evidence

ORD record
ord-ec0e64f4c0134dd6a57046432d689474
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

Loading…