N-Methylallylamine → HCID 178457228, compound

HRID 967182Notes

Reaction equation

HRID 967182 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:24])[N:10]([CH2:12][CH2:13][C@H:14]2[CH2:19][CH2:18][C@H:17](/[CH:20]=[CH:21]/[CH2:22]Cl)[CH2:16][CH2:15]2)[CH3:11])=[CH:4][CH:3]=1.[CH2:25]([NH:28][CH3:29])[CH:26]=[CH2:27]>CN(C)C(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:24])[N:10]([CH2:12][CH2:13][C@H:14]2[CH2:19][CH2:18][C@H:17](/[CH:20]=[CH:21]/[CH2:22][N:28]([CH2:25][CH:26]=[CH2:27])[CH3:29])[CH2:16][CH2:15]2)[CH3:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 69391N-MethylallylamineHCID 178483623HCID 178483623, compound

Product 1

HCID 178457228HCID 178457228, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In analogy to the method described in example 12.1, trans-{2-[4-(3-chloro-(E)-propenyl)-cyclohexyl]-ethyl}-methyl-carbamic acid 4-chloro-phenyl ester was reacted with N-allyl-methyl-amine in N,N-dimethylacetamide at room temperature to yield trans-(2-{4-[3-(allyl-methyl-amino)-(E)-propenyl]-cyclohexyl}-ethyl)-methyl-carbamic acid 4-chloro-phenyl ester as light yellow viscous oil, MS: 405 (MH+, 1Cl).

Sources & evidence

ORD record
ord-41643eae08f64ccfab75a25c9dcc8e90
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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