N-Methylallylamine → HCID 178457238, compound

HRID 967192Notes

Reaction equation

HRID 967192 reaction equation
Br[CH2:2]/[CH:3]=[CH:4]/[CH2:5][O:6][CH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][N:15]([CH3:29])[S:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:10][CH2:9]1.[CH2:30]([NH:33][CH3:34])[CH:31]=[CH2:32]>CN(C)C(=O)C>[CH2:30]([N:33]([CH3:34])[CH2:2]/[CH:3]=[CH:4]/[CH2:5][O:6][CH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][N:15]([CH3:29])[S:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:10][CH2:9]1)[CH:31]=[CH2:32]

Participants

4

Reactant 2

HCID 69391N-MethylallylamineHCID 178484053HCID 178484053, compound

Product 1

HCID 178457238HCID 178457238, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In analogy to the method described in example 12.1, trans-N-[4-(4-bromo-(E)-but-2-enyloxymethyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide was reacted with N-allyl-methyl-amine in N,N-dimethylacetamide at room temperature to yield trans-N-{4-[4-(allyl-methyl-amino)-(E)-but-2-enyloxymethyl]-cyclohexylmethyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide as light yellow viscous oil, MS: 489 (MH+).

Sources & evidence

ORD record
ord-a2ef48ca991d47c59183689d6c9dee27
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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