Diethanolamine → HCID 178484065, compound

HRID 967208Notes

Reaction equation

HRID 967208 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:26])[N:10]([CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][O:20][CH2:21][CH2:22][CH2:23][CH2:24]Br)[CH2:15][CH2:14]2)[CH3:11])=[CH:4][CH:3]=1.[OH:27][CH2:28][CH2:29][NH:30][CH2:31][CH2:32][OH:33]>CN(C)C(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:26])[N:10]([CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][O:20][CH2:21][CH2:22][CH2:23][CH2:24][N:30]([CH2:31][CH2:32][OH:33])[CH2:29][CH2:28][OH:27])[CH2:15][CH2:14]2)[CH3:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8113DiethanolamineHCID 178484052HCID 178484052, compound

Product 1

HCID 178484065HCID 178484065, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In analogy to the method described in example 12.1, trans-[4-(4-bromo-butoxymethyl)-cyclohexylmethyl]-methyl-carbamic acid 4-chloro-phenyl ester was reacted with bis-(2-hydroxy-ethyl)-amine in N,N-dimethylacetamide at 50° C. for 3 hours to yield trans-(4-{4-[bis-(2-hydroxy-ethyl)-amino]-butoxymethyl}-cyclohexylmethyl)-methyl-carbamic acid 4-chloro-phenyl ester as colorless viscous oil, MS: 471 (MH+, 1Cl).

Sources & evidence

ORD record
ord-4f6d1ee35af74c639e01f9db1255a13a
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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