Hexane → HCID 10879942, compound

2,4-Dibromo-1,3-thiazole (2.0 g, 8.2 mmol) and CuI (312 mg, 1.64 mmol) were combined in DME (25 mL) and argon gas was bubbled through the suspension for several minutes to deoxygenate the mixture. Triethylamine (5.7 mL, 41 mmol) and PdCl2(PPh3)2 (580 mg, 0.82 mmol) were added, and then phenylacetylene (0.90 mL, 8.6 mmol) was added dropwise. The reaction was stirred for 4 h at ambient temperature at which point GC/MS analysis showed the reaction to be complete. The mixture was filtered through Celite™, the filter pad was washed thoroughly with Ethyl acetate and the combined filtrates were then concentrated in vacuo. The residue was dissolved in ethyl acetate (200 mL), washed with water (200 mL), brine (200 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography eluting with hexane, then 97:3 hexane:ethyl acetate to afford pure 4-bromo-2-(phenylethynyl)-1,3-thiazole (1.0 g, 46% yield) as a colorless solid. M.p. 79–82° C.; 1H NMR (CDCl3, 300 MHz) δ 7.60–7.56 (m, 2H) 7.45–7.26 (m, 3H), 7.26 (s, 1H). MS (EI ionization) 263 (M+, 79Br), 265 (M+, 81Br).

1. customargon gas was bubbled through the suspension for several minutes
2. customto deoxygenate the mixture
3. customthe reaction
4. filtrationThe mixture was filtered through Celite™
5. washthe filter pad was washed thoroughly with Ethyl acetate
6. concentrationthe combined filtrates were then concentrated in vacuo
7. dissolutionThe residue was dissolved in ethyl acetate (200 mL)
8. washwashed with water (200 mL), brine (200 mL)
9. dry with materialdried over Na2SO4
10. filtrationfiltered
11. concentrationconcentrated in vacuo
12. customThe residue was purified by column chromatography
13. washeluting with hexane

ORD record

ord-5a8a5fe60a414b10b360815f31ea8115

Source dataset

uspto-grants-2005_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06956049B1