Hydrochloric Acid → 5-methyl-4-[4-[4-(oxan-4-yl)-1-(2-pyrrolidin-1-ylethyl)imidazol-2-yl]piperidin-1-yl]-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one

HRID 97035Notes

Reaction equation

HRID 97035 reaction equation
[C:56]([O:57][CH2:58][CH2:59][CH2:60][CH3:61])(=[O:62])[CH3:63].[CH2:52]([OH:53])[CH2:54][CH3:55].[Cl:28][c:29]1[c:30]2[c:31]([n:32][cH:33][n:34]1)[NH:35][C:36](=[O:40])[CH2:37][CH:38]2[CH3:39].[ClH:1].[ClH:2].[ClH:3].[N:41]12[CH2:42][CH2:43][CH2:44][N:45]=[C:46]1[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51]2.[N:4]1([CH2:9][CH2:10][n:11]2[c:12]([CH:22]3[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]3)[n:13][c:14]([CH:16]3[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)[cH:15]2)[CH2:5][CH2:6][CH2:7][CH2:8]1>>[N:4]1([CH2:9][CH2:10][n:11]2[c:12]([CH:22]3[CH2:23][CH2:24][N:25]([c:29]4[c:30]5[c:31]([n:32][cH:33][n:34]4)[NH:35][C:36](=[O:40])[CH2:37][CH:38]5[CH3:39])[CH2:26][CH2:27]3)[n:13][c:14]([CH:16]3[CH2:17][CH2:18][O:19][CH2:20][CH2:21]3)[cH:15]2)[CH2:5][CH2:6][CH2:7][CH2:8]1

Participants

7

Reactant 6

HCID 313Hydrochloric Acid3×HCID 10311-PropanolHCID 31272Butyl AcetateHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 671119654-(1-(2-pyrrolidin-1-yl-ethyl)-4-(tetrahydro-pyran-4-yl)-1H-imidazol-2-yl)-piperidineHCID 866665664-chloro-5-methyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one

Product 1

HCID 671120565-methyl-4-[4-[4-(oxan-4-yl)-1-(2-pyrrolidin-1-ylethyl)imidazol-2-yl]piperidin-1-yl]-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one

Sources & evidence

ORD record
ord-1c9aae8ea423435e88ca39cf97de9592
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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