Tetrahydrofuran → HCID 59019996, compound

HRID 971168Notes

Reaction equation

HRID 971168 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:18][C:19](=O)[C:20]2[CH:25]=[CH:24][C:23]([C:26]([CH3:35])([CH3:34])[CH2:27][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[CH:22][CH:21]=2)=[C:6]([CH:17]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=1)=[O:8].C1COCC1>Cl.O1CCOCC1>[Cl:1][C:2]1[CH:17]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:18]=[C:19]([C:20]1[CH:25]=[CH:24][C:23]([C:26]([CH3:35])([CH3:34])[CH2:27][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[CH:22][CH:21]=1)[N:9]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=1)[C:7]2=[O:8]

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 59020235HCID 59020235, compound

Product 1

HCID 59019996HCID 59019996, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of the product from Example 197 (15.0 mg, 0.028 mmol) in 5 ml of 4N HCl in dioxane and 0.5 mL of THF was refluxed for 6 hr. The mixture was cooled to rt and purified with reverse phase HPLC to give the desired product as white solid. MS found: (M+1)+=509.1.

Workup

  1. custompurified with reverse phase HPLC

Sources & evidence

ORD record
ord-be75cf8759fc47b4bf42f542e8ab2aec
Source dataset
uspto-grants-2007_12
Patent number
US07312214B2

Reaction notes

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