Morpholine → HCID 14547438, compound

HRID 971203Notes

Reaction equation

HRID 971203 reaction equation
[H-].[Na+].[NH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.Cl.Cl[CH2:11][C:12]([NH2:14])=[NH:13]>C1COCC1>[O:6]1[CH2:7][CH2:8][N:3]([CH2:11][C:12]([NH2:14])=[NH:13])[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 24758Sodium hydrideHCID 27769572-Chloroacetamidine monohydrochloride

Product 1

HCID 14547438HCID 14547438, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Sodium hydride (2.4 g, 60 mmol, 60%) was added to a solution of morpholine (5.2 g, 60 mmol) in THF (40 mL, anhydrous) and stirred for 30 min at room temperature under nitrogen. Chloroacetamidine hydrochloride (2.58 g, 20 mmol) was added to this solution in one portion and stirred at 50° C. overnight. Solvent was removed under reduced pressure and the dark brown oily residue was directly used in the next step.

Workup

  1. stirringstirred at 50° C. overnight
  2. customSolvent was removed under reduced pressure

Sources & evidence

ORD record
ord-7cf2c5a69a3d4e238f1b207eb22ecc43
Source dataset
uspto-grants-2007_12
Patent number
US07312330B2

Reaction notes

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