反应详情

Boc-Lys(Xys)-OH (124.4 mg, 0.3 m.mol), Nε -benzylsulfonyllysine (90 mg., 0.3 m.mol) and Boc-Lys-(2-Cl-Z)-OH.t-butylamine salt (146.4 mg, 0.3 m.mol) are each treated with hydrogen fluoride (2 ml) in the presence of anisole (0.1 ml) at -20° C. for one hour. After the hydrogen fluoride is distilled off, the residue is dissolved in water (50 ml). An aliquot of the solution is taken and the lysine content of the sample is determined by an amino acid analyzer. The % yields of lysine are calculated.

1. distillationAfter the hydrogen fluoride is distilled off
2. dissolutionthe residue is dissolved in water (50 ml)