Piperidine → HCID 178429185, compound

HRID 973845Notes

Reaction equation

HRID 973845 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([SH:7])[NH:4][N:3]=1.[C:8](OCC)(=[O:13])[CH2:9][C:10]([CH3:12])=O.N1CCCCC1>C(O)C>[OH:13][C:8]1[N:3]2[N:4]=[C:5]([SH:7])[N:6]=[C:2]2[N:1]=[C:10]([CH3:12])[CH:9]=1

Participants

5

Reactant 3

HCID 8082PiperidineHCID 8868Ethyl AcetoacetateHCID 1785092965-amino-1H-1,2,4-triazole-3-thiol

Product 1

HCID 178429185HCID 178429185, compoundYield 37.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-amino-5-mercapto-s-triazole (10 g), ethyl acetoacetate (34 g), piperidine (10 ml) and ethanol (300 ml) was refluxed for four hours. After removing the solvent by distillation under reduced pressure, 150 ml water was added, the mixture was neutralized to pH 7.0 with hydrochloric acid and cooled, giving 5.9 g of the objective compound.

Workup

  1. temperaturewas refluxed for four hours
  2. customAfter removing the solvent
  3. distillationby distillation under reduced pressure, 150 ml water
  4. additionwas added
  5. temperaturecooled

Sources & evidence

ORD record
ord-da9e5a02aec943218c6689899b198de5
Source dataset
uspto-grants-1991_11
Patent number
US05064953

Reaction notes

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