Triethylamine → HCID 14876001, compound

HRID 974190Notes

Reaction equation

HRID 974190 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH:10]=[O:11])[CH2:6][CH2:5]1.C(N(CC)CC)C.[C:19](Cl)(=[O:23])[C:20]([CH3:22])=[CH2:21]>ClCCl.C(C1C=C(C)C=C(C(C)(C)C)C=1O)(C)(C)C>[CH:10]([N:7]1[CH2:8][CH2:9][N:4]([CH2:3][CH2:2][NH:1][C:19](=[O:23])[C:20]([CH3:22])=[CH2:21])[CH2:5][CH2:6]1)=[O:11]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 13528Methacryloyl chlorideHCID 148760004-(2-Aminoethyl)piperazine-1-carbaldehyde

Product 1

HCID 14876001HCID 14876001, compoundYield 44%

Reagents, catalysts & solvents 2

HCID 314042,6-Di-tert-butyl-4-methylphenolCatalystHCID 6344DichloromethaneSolvent

Procedure

117.9 g (0.75 mol) of N-2-aminoethyl-N'-formylpiperazine, 85.8 g (0.85 mol) of triethylamine and 100 mg of 2,6-di-tert.-butyl-4-methylphenol were reacted in 230 ml of dichloromethane with 78.4 g (0.75 mol) of methacryloyl chloride as described in Example 1 and the mixture was worked up. 73.9 g (44% of theory) of N-formyl-N'-(methacryloylaminoethyl)piperazine were obtained in this manner as a colorless oil.

Sources & evidence

ORD record
ord-80c1378b2dc1428292b69c9bee6f105d
Source dataset
uspto-grants-1991_11
Patent number
US05068264

Reaction notes

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