反应详情

温度

80 °C

To a solution of methyl 5-fluorosalicylate (3.93 g, 23.1 mmol) in dry N,N-dimethylformamide (30 ml) was added sodium hydride (1.1 g, 50% oil dispersion). After hydrogen gas evolution had ceased, the mixture was cooled in an ice-bath, and dimethylthiocarbamoyl chloride (3.71 g, 30.0 mmol) was added. The mixture was stirred at 80° C. for one hour, cooled, and poured into water (100 ml). The product was extracted with diethyl ether (2×), and the combined organic extracts were washed with water, 5% aqueous potassium hydroxide, water, dried (sodium sulfate), and evaporated. The solid obtained was recrystallized from diethyl ether-hexane to afford 3.16 g (53%) of O-2-carbomethoxy-4-fluorophenyl dimethylthiocarbamate. The 90 MHz NMR spectrum in chloroform-d was in accord with the desired structure.

1. temperaturethe mixture was cooled in an ice-bath
2. temperaturecooled
3. extractionThe product was extracted with diethyl ether (2×)
4. washthe combined organic extracts were washed with water, 5% aqueous potassium hydroxide, water
5. dry with materialdried (sodium sulfate)
6. customevaporated
7. customThe solid obtained
8. customwas recrystallized from diethyl ether-hexane