Potassium Carbonate → HCID 54514614, compound

HRID 974336Notes

Reaction equation

HRID 974336 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][NH:7][CH2:8][CH2:9][C:10]=2[N:11]=1.C(=O)([O-])[O-].[K+].[K+].[F:18][C:19]([F:31])([F:30])[C:20]1[CH:21]=[C:22]([CH:27]=[CH:28][CH:29]=1)[CH:23]=[CH:24][CH2:25]Br>CN(C)C=O>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:25][CH:24]=[CH:23][C:22]3[CH:27]=[CH:28][CH:29]=[C:20]([C:19]([F:18])([F:30])[F:31])[CH:21]=3)[CH2:8][CH2:9][C:10]=2[N:11]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 54572020HCID 54572020, compound

Product 1

HCID 54514614HCID 54514614, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared analogously to Example 1 from 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine, potassium carbonate and 3-trifluoromethyl-cinnamyl bromide in anhydrous dimethylformamide for one hour at 20° C. Yield: 41% of theory, Melting point: 102°-105° C. (petroleum ether).

Sources & evidence

ORD record
ord-819ce6c86a8948829ab494635cf2eb1f
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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