Chloride → 6'-Bromo-4-(trifluoromethyl)spiro[cyclohexane-1,2'-inden]-1'(3'H)-one
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([I:24])[c:5]([CH2:6][C:7]2([C:17]([O:19][CH2:18][CH3:20])=[O:21])[CH2:8][CH2:9][CH:10]([C:13]([F:14])([F:15])[F:16])[CH2:11][CH2:12]2)[cH:22][cH:23]1.[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH:28]([Mg+:29])([CH3:30])[CH3:31].[Cl-:25].[Cl-:27].[Li+:26]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:22][cH:23]1)[CH2:6][C:7]1([CH2:8][CH2:9][CH:10]([C:13]([F:14])([F:15])[F:16])[CH2:11][CH2:12]1)[C:17]2=[O:19]Participants
6
Sources & evidence
- ORD record
- ord-da648cfd81154fb6b0c75b766e8fc898
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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