反应详情

To a solution of 10.0 g (0.028 mole) of ethyl 3,3-bis(4-fluorophenyl)-2-(1H-tetrazol-5-yl)-2-propenoate [prepared in Example 2] in 75 mL of N,N-dimethylformamide was added 1.2 g of 60% sodium hydride (0.03 mole) in mineral oil was added. After stirring for 0.5 hour, the sodium hydride had dissolved and 8.5 g (0.056 mole) of iodoethane was added. The solution was stirred at room temperature for 16 hours, diluted to 400 mL with water and extracted with CH2Cl2. The extracts were dried and concentrated in vacuo. The residue was triturated with hexane to remove mineral oil. The residue was absorbed onto silica gel by dissolving in CH2Cl2 and adding dry silica gel, then concentrating in vacuo to a dry powder. This material was transferred to the top of a silica gel column and eluted with 10% (v/v) ethyl acetate in hexane to give 4.9 g (45.5%) of the title compound; m.p.=113°-114.5° C.

1. additionwas added
2. stirringThe solution was stirred at room temperature for 16 hours
3. extractionextracted with CH2Cl2
4. customThe extracts were dried
5. concentrationconcentrated in vacuo
6. customThe residue was triturated with hexane
7. customto remove mineral oil
8. customThe residue was absorbed onto silica gel
9. dissolutionby dissolving in CH2Cl2
10. additionadding dry silica gel
11. concentrationconcentrating in vacuo to a dry powder
12. washeluted with 10% (v/v) ethyl acetate in hexane