Sodium Bicarbonate → HCID 19969624, compound

HRID 974823Notes

Reaction equation

HRID 974823 reaction equation
[C:1]([NH:11][C:12]([CH2:26][CH2:27][CH2:28][CH:29]1OCC[O:30]1)([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].C([O-])(O)=O.[Na+]>Cl>[C:1]([NH:11][C:12]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)([CH2:26][CH2:27][CH2:28][CH:29]=[O:30])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 19969644HCID 19969644, compound

Product 1

HCID 19969624HCID 19969624, compoundYield 119.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The amine of step (b) (25 g) was dissolved in 1N HCl (300 ml) and stirred at room temperature overnight to hydrolyze the acetal group. The solution was neutralized with NaHCO3 and the amine was extracted into chloroform. Concentration of the chloroform afforded the subtitle compound (27 g) as a yellow solid.

Workup

  1. extractionthe amine was extracted into chloroform

Sources & evidence

ORD record
ord-fb7223320b0c4455ad819d7c3e33d49f
Source dataset
uspto-grants-1997_03
Patent number
US05607935

Reaction notes

Loading…