Hydrochloric Acid → HCID 19972073, compound

HRID 975606Notes

Reaction equation

HRID 975606 reaction equation
O1CCCC1.[C:6]([CH2:9][CH2:10][C:11](=[N:22][NH:23][C:24]([NH:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:36])[F:35])=[CH:29][CH:28]=1)=[O:25])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=1)(=[O:8])[NH2:7].C([BH3-])#N.[Na+].Cl>CO>[C:6]([CH2:9][CH2:10][CH:11]([NH:22][NH:23][C:24]([NH:26][C:27]1[CH:28]=[CH:29][C:30]([O:33][C:34]([F:35])([F:36])[F:37])=[CH:31][CH:32]=1)=[O:25])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=1)(=[O:8])[NH2:7]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 5003444Sodium cyanoborohydrideHCID 54270162HCID 54270162, compound

Product 1

HCID 19972073HCID 19972073, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a mixed solvent of 15 ml of tetrahydrofuran and 15 ml of methanol was dissoved 0.46 g (1.0 mmole) of 2-[3-carbamoyl-1-(3-trifluoromethylphenyl)propylidene]-N-(4-trifluoromethoxyphenyl)hydrazinecarboxamide, after which to the resulting solution were added 0.46 g (7.7 mmoles) of sodium cyanoborohydride and then 5 drops of a saturated methanolic solution of hydrochloric acid, and the reaction was carried out for 36 hours.

Sources & evidence

ORD record
ord-b3cfb861071f4dc58bd40fb110f631a6
Source dataset
uspto-grants-1997_03
Patent number
US05608109

Reaction notes

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