Potassium Iodide → HCID 19968358, compound

HRID 975817Notes

Reaction equation

HRID 975817 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[CH:13]12[N:20]([C:21](=[O:32])[CH:22]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:23][CH2:24]Br)[CH:17]([CH2:18][CH2:19]1)[CH2:16][CH2:15][CH2:14]2.C(N(C(C)C)CC)(C)C.[I-].[K+].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>CN(C)C=O>[CH:17]12[N:20]([C:21](=[O:32])[CH:22]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:23][CH2:24][N:10]3[CH2:9][CH2:8][N:7]([C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=4)[CH2:12][CH2:11]3)[CH:13]([CH2:19][CH2:18]1)[CH2:14][CH2:15][CH2:16]2

Participants

7

Reactant 5

HCID 4875Potassium IodideHCID 81531DiisopropylethylamineHCID 944591-(2-Pyridyl)piperazineHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 19968355HCID 19968355, compound

Product 1

HCID 19968358HCID 19968358, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared from 4-(pyridin-2-yl)-piperazine (1.0 g, 6.0 mmole), 1-(8-aza-bicyclo[3.2.1]oct-8-yl)-4-bromo-2-phenyl-butan-1-one (1.6 g, 4.76 mmole), diisopropylethylamine (0.9 g, 7.0 mmole) and potassium iodide (0.8 g, 5.0 mmole) in dimethylformamide (30 mL) in the manner described in example 2 to yield 1.1 g of product as the dihydrochloride, m.p. 196°-236° C.

Sources & evidence

ORD record
ord-12f30653cff240f4b9ea000d77131929
Source dataset
uspto-grants-1997_03
Patent number
US05610154

Reaction notes

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