Nicotinic Acid → 1-(1-Naphthyl)-2-(2-(nicotinoylamino)ethoxy]ethanol hydrochloride

0.62 g of N,N'-dicyclohexylcarbodiimide was added to a mixture of 0.7 g of 2-(2-aminoethoxy)-1-(1-naphthyl)ethanol, 0.37 g of nicotinic acid, 0.41 g of 1-hydroxybenzotriazole, 0.42 ml of triethylamine and 4 ml of tetrahydrofuran with ice cooling. The resulting mixture was stirred at the same temperature for 5 minutes and further at room temperature for 1 hour. To the reaction mixture was added 6 ml of ethyl acetate. The insolubles were removed by filtration. To the filtrate were added 15 ml of ethyl acetate and 20 ml of water. The resulting mixture was adjusted to pH 2 with 6N hydrochloric acid. The aqueous layer was separated. The organic layer was extracted twice each with 10 ml of water. The extracts were combined with the previously separated aqueous layer. To the combined aqueous layer was added 30 ml of chloroform and the resulting mixture was adjusted to pH 10.5 with potassium carbonate. The organic layer was separated, washed with water, and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure. The residue thus obtained was purified by column chromatography (eluant: chloroform/ethanol=10/1) to obtain an oily product. The oily product was dissolved in 7 ml of acetone. To the solution was added 0.43 ml of a 5N dry hydrogen chloride-ethanol solution. The resulting mixture was stirred at room temperature for 1 hour. To the reaction mixture was added 3 ml of diethyl ether. The resulting mixture was stirred at the same temperature for 1 hour. The resulting crystals were collected by filtration and dried to obtain 0.67 g of 1-(1-naphthyl)-2-[2-(nicotinoylamino)ethoxy]ethanol hydrochloride (compound no. 269).

1. customThe insolubles were removed by filtration
2. additionTo the filtrate were added 15 ml of ethyl acetate and 20 ml of water
3. customThe aqueous layer was separated
4. extractionThe organic layer was extracted twice each with 10 ml of water
5. additionTo the combined aqueous layer was added 30 ml of chloroform
6. customThe organic layer was separated
7. washwashed with water
8. dry with materialdried over anhydrous magnesium sulfate
9. customThe solvent was removed by distillation under reduced pressure
10. customThe residue thus obtained
11. customwas purified by column chromatography (eluant: chloroform/ethanol=10/1)
12. customto obtain an oily product
13. stirringThe resulting mixture was stirred at room temperature for 1 hour
14. stirringThe resulting mixture was stirred at the same temperature for 1 hour
15. filtrationThe resulting crystals were collected by filtration
16. customdried

ORD record

ord-00fed8616d6b4bbe983d25469a1a6825

Source dataset

uspto-grants-1997_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05612381