反应详情

温度

130 °C

A tube was charged with a stir bar, N-benzyloxy-N-(1-ethylpropyl)amine (2.0 g, 10.3 mmole), tetrahydrofuran (5 mL), triethylamine (4.31 mL), N-methyl-N-phenylcarbamoyl chloride (1.75 g, 10.3 mmole), and 4-dimethylaminopyridine (1 mg). The tube was flushed with nitrogen, sealed and then heated to 130° C. After 48 hours the reaction mixture was cooled to ambient temperature and concentrated under vacuum. The residue was purified by chromatography (silica gel; 9:1 hexanes:ethyl acetate) to provide 2.0 g of 1-benzyloxy-1-(1-ethylpropyl)-3-methyl-3-phenylurea.

1. additionA tube was charged with a stir bar
2. customThe tube was flushed with nitrogen
3. customsealed
4. temperatureAfter 48 hours the reaction mixture was cooled to ambient temperature
5. concentrationconcentrated under vacuum
6. customThe residue was purified by chromatography (silica gel; 9:1 hexanes:ethyl acetate)