Potassium Carbonate → HCID 19965391, compound

HRID 977159Notes

Reaction equation

HRID 977159 reaction equation
[C:1]([C:3]1[C:4]2[N:5]([CH:9]=[C:10]([C:12]3[CH:32]=[CH:31][C:15]([C:16]([NH:18][CH2:19][CH2:20][C:21]([O:23]CC4C=CC=CC=4)=[O:22])=[O:17])=[CH:14][CH:13]=3)[N:11]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2].Cl.NO.C([O-])([O-])=O.[K+].[K+]>CO>[C:1]([C:3]1[C:4]2[N:5]([CH:9]=[C:10]([C:12]3[CH:13]=[CH:14][C:15]([C:16]([NH:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[O:17])=[CH:31][CH:32]=3)[N:11]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 19965295HCID 19965295, compound

Product 1

HCID 19965391HCID 19965391, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.55 g of benzyl 3-[4-(8-cyanoimidazo[1,2-a]pyridin-2-yl)benzamido]propionate [obtainable by reacting 4-(8-cyanoimidazo[1,2-a]pyridin-2-yl)benzoic acid with benzyl 3-aminopropionate as in Example 32] is boiled in 30 ml of methanol with 0.27 g of hydroxylamine hydrochloride in the presence of 0.72 g of K2CO3 for 4 h. After cooling, the precipitate is filtered off with suction and washed successively with water and methanol. 3-[4-(8-cyanoimidazo[1,2-a]pyridin-2-yl)benzamido]propionic acid, m.p. 212°-215°, is obtained.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitate is filtered off with suction
  3. washwashed successively with water and methanol

Sources & evidence

ORD record
ord-0310cb5924904d468a0f348d31a342fa
Source dataset
uspto-grants-1997_03
Patent number
US05614531

Reaction notes

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