Hydrochloric Acid → HCID 131719941, compound

HRID 977221Notes

Reaction equation

HRID 977221 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:20][CH:19]([C:21]([N:23]3[CH2:28][CH2:27][N:26]([CH2:29][C:30]([O:32][CH2:33][C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[O:31])[CH2:25][CH2:24]3)=[O:22])[O:18][C:17]2=[O:40])=[CH:12][CH:11]=1)=O)(C)(C)C.[ClH:41]>C(OCC)(=O)C>[ClH:41].[ClH:41].[NH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:20][CH:19]([C:21]([N:23]3[CH2:24][CH2:25][N:26]([CH2:29][C:30]([O:32][CH2:33][C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)=[O:31])[CH2:27][CH2:28]3)=[O:22])[O:18][C:17]2=[O:40])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19965490HCID 19965490, compound

Product 1

HCID 131719941HCID 131719941, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

0.74 g of benzyl 2-{1-[3-(4-tert-butoxycarbonylaminomethylphenyl)-2-oxo-5-oxazolidinylcarbonyl]-4-piperazinyl}acetate is stirred in 30 ml of HCl solution in ethyl acetate at room temperature. The precipitate formed is filtered off through suction, washed with a little ethyl acetate and dried. Benzyl 2-{1-[3-(4-aminomethylphenyl)-2-oxo-5-oxazolidinylcarbonyl]-4-piperazinyl}acetate, dihydrochloride, is obtained, m.p. 224°-226°.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered off through suction
  3. washwashed with a little ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-4bb6449a82b24603a0b0316b7ba745b7
Source dataset
uspto-grants-1997_03
Patent number
US05614535

Reaction notes

Loading…