Phenethylamine → HCID 9794284, compound

HRID 977942Notes

Reaction equation

HRID 977942 reaction equation
[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:10]([O:14][CH3:15])(=[O:13])[CH:11]=[CH2:12]>CO>[CH3:15][O:14][C:10](=[O:13])[CH2:11][CH2:12][NH:9][CH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 7294Methyl Acrylate

Product 1

HCID 9794284HCID 9794284, compoundYield 76.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Phenethylamine (121 g) is dissolved in methanol (500 ml) and thereto is added dropwise methyl acrylate (86 g) at room temperature. The mixture is stirred for 4 hours and then distilled to remove the solvent to give N-phenethyl-β-alanine methyl ester (157.8 g, 76%), b.p. 124°-127° C. (1.2 mmHg).

Workup

  1. distillationdistilled
  2. customto remove the solvent

Sources & evidence

ORD record
ord-f0ba5c3e23e14822b993c43074aa7818
Source dataset
uspto-grants-1987_05
Patent number
US04663319

Reaction notes

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