反应详情

A mixture of 9.9 gm 3-hydroxy-5-bromophthalide, 5.8 gm p-methoxystyrene, 0.09 gm palladium acetate, 0.47 gm tri-(o-tolyl)-phosphine, 7 ml triethylamine and 35 ml dimethylsulfoxide were heated with stirring at 95° for 5 hours. The reaction mixture was cooled and added to 400 ml water. The product was extracted into ethyl acetate, which solution was washed with water and dried over magnesium sulfate. Removal of solvent left 8.0 gm yellow solid melting at 140°-148°.

1. temperaturewere heated
2. temperatureThe reaction mixture was cooled
3. extractionThe product was extracted into ethyl acetate, which solution
4. washwas washed with water
5. dry with materialdried over magnesium sulfate
6. customRemoval of solvent
7. waitleft 8.0 gm yellow solid melting at 140°-148°