Acetic Acid → HCID 13576373, compound

HRID 979041Notes

Reaction equation

HRID 979041 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2OC(=O)[C:11](=[C:15]=[O:16])[CH2:10]2)=[CH:5][CH:4]=1)#[N:2].O.[NH2:18][NH2:19].CN(C)[CH:22]=[O:23].C(O)(=O)C>C(O)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]([CH2:22][OH:23])[CH2:11][C:15](=[O:16])[NH:18][N:19]=2)=[CH:7][CH:8]=1)#[N:2]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 6228DimethylformamideHCID 24654Hydrazine hydrate (1:1)HCID 131715139HCID 131715139, compound

Product 1

HCID 13576373HCID 13576373, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

3.0 g (0.014 mol) of 4-(4-cyanophenyl)-carbonyl-γ-butyrolactone and 1 ml (0.021 mol) of hydrazine hydrate are stirred in 50 ml of ethanol and 50 ml of dimethylformamide at room temperature for 10 hours. After addition of 1 ml of acetic acid, the mixture is stirred at 80° C. for 18 hours and worked up as above.

Sources & evidence

ORD record
ord-7bc602a621804732a5beb7d125085104
Source dataset
uspto-grants-1987_05
Patent number
US04666902

Reaction notes

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