Potassium Carbonate → HCID 13689403, compound

HRID 979341Notes

Reaction equation

HRID 979341 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:3][CH2:2]1.C1(C)CCC(C(C)C)C(S(O[CH2:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([F:45])([F:44])[F:43])[CH:37]=2)(=O)=O)C1.C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[F:43][C:42]([F:44])([F:45])[C:38]1[CH:37]=[C:36]([CH2:35][CH2:34][N:1]2[CH2:2][CH2:3][CH:4]([CH:7]3[C:13]4=[CH:14][CH:15]=[CH:16][N:12]4[CH2:11][C:10]4[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=4[O:8]3)[CH2:5][CH2:6]2)[CH:41]=[CH:40][CH:39]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1368935811-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepineHCID 54410630HCID 54410630, compound

Product 1

HCID 13689403HCID 13689403, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
65 °C

Procedure

A mixture of 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (6.15 g, 0.023 mole), 2-(3-trifluoromethylphenyl)ethyl menthanesulfonate (7.27 g, 0.027 mole) and K2CO3 (10.6 g) in 125 ml dimethylformamide was heated at 65° C. for 5 hours.

Sources & evidence

ORD record
ord-43c97d6636ac4101acc5cc375cdf2f73
Source dataset
uspto-grants-1987_05
Patent number
US04667039

Reaction notes

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