反应详情

A mixture of 11.0 g of hydroquinone, 80 ml of isopropanol, 4.1 g of sodium hydroxide in 4.5 ml water, 9.9 g of cyclopropylmethyl chloride and 0.5 g of potassium iodide is stirred under reflux for 12 hours. The solvent is evaporated and the residue is extracted with ether. The ether extract is washed successively with water, sodium bicarbonate solution, dilute sodium bisulfite solution, water and sodium chloride solution and dried. The crude product obtained after evaporation of solvent is purified by preparative chromatography on silica gel, using first toluene and then toluene-ethyl acetate (90:5 to 85:15) as eluent to yield p-(cyclopropylmethoxy)-phenol, m.p. 49°-52°.

1. temperatureunder reflux for 12 hours
2. customThe solvent is evaporated
3. extractionthe residue is extracted with ether
4. extractionThe ether extract
5. washis washed successively with water, sodium bicarbonate solution, dilute sodium bisulfite solution, water and sodium chloride solution
6. customdried
7. customThe crude product obtained
8. customafter evaporation of solvent
9. customis purified by preparative chromatography on silica gel