反应详情

4 g of 3-(4-(2-methoxyethoxy)phenoxy)-1,2-epoxypropane, 5.8 g of the sulphate of N-2-aminoethyl-4-morpholinecarboxamide, and 5.8 g of K2CO3 were refluxed in 2-propanol for 2 days. The mixture was filtered and concentrated in vacuo. The residue was dissolved in methylene chloride and washed with H2O. The organic phase was dried over Na2SO4, filtered and evaporated. The product was recrystallized from ethyl acetate. Yield 2.3 g. Melting point 69° C. (base). The structure was determined using NMR and equivalent weight.

1. filtrationThe mixture was filtered
2. concentrationconcentrated in vacuo
3. dissolutionThe residue was dissolved in methylene chloride
4. washwashed with H2O
5. dry with materialThe organic phase was dried over Na2SO4
6. filtrationfiltered
7. customevaporated
8. customThe product was recrystallized from ethyl acetate