Hydrochloric Acid → HCID 13317892, compound

HRID 980457Notes

Reaction equation

HRID 980457 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:13])[CH2:11][CH3:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1.[CH2:19]=O.Cl>C(OCC)(=O)C>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:13])[CH:11]([CH3:19])[CH2:12][N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 31268PyrrolidineHCID 37734351-(4-isopropylphenyl)propan-1-one

Product 1

HCID 13317892HCID 13317892, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 10.00 g of 4'-isopropylpropiophenone in 80 ml of ethyl acetate were added 2.00 g of pyrrolidine and 2.50 g of paraformaldehyde. The mixture was acidified by the addition of gaseous hydrogen chloride and refluxed for 4 hours.

Workup

  1. temperaturerefluxed for 4 hours

Sources & evidence

ORD record
ord-bcb7e2ecde3147c4ba174809ad2a8cf4
Source dataset
uspto-grants-1987_01
Patent number
US04638009

Reaction notes

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