Methyl fluorosulfate → HCID 20220803, compound

HRID 980972Notes

Reaction equation

HRID 980972 reaction equation
[CH:1]([NH:3][CH2:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)=[O:6])=[S:2].[CH3:18]OS(F)(=O)=O.[CH3:24][O:25][CH2:26][C:27](Cl)=[O:28]>C(N(CC)CC)C>[CH3:24][O:25][CH:26]1[CH:1]([S:2][CH3:18])[N:3]([CH2:4][C:5]([O:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[O:6])[C:27]1=[O:28]

Participants

5

Reactant 3

HCID 9870Methyl fluorosulfateHCID 96623Methoxyacetyl chlorideHCID 20220776HCID 20220776, compound

Product 1

HCID 20220803HCID 20220803, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Following the procedure of Preparation 24, but using p-nitrobenzyl thioformylglycinate (254 mg.), magic methyl (81 μl.), triethylamine (350 μl) and methoxyacetyl chloride (91 μl.), there were obtained 26 mg of the desired product.

Workup

  1. customthe procedure of Preparation 24

Sources & evidence

ORD record
ord-a0c755fa9b6244549cab249d6f04017a
Source dataset
uspto-grants-1987_01
Patent number
US04639441

Reaction notes

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