HRID980995

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

HCID7519

Anisole

C7H8O

结构：O=C(Cc1ccccc1)NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(C=Cc3cccnc3)CS[C@H]12

HCID131714373

未命名化合物

PRODUCTS

生成物

结构：O=C(Cc1ccccc1)NC1C(=O)N2C(C(=O)O)=C(C=Cc3cccnc3)CS[C@H]12.O=C(O)C(F)(F)F

HCID131714374

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID7914

Isopropyl ether

C6H14O

PROCEDURE

实验过程

A mixture of benzhydryl 7-phenylacetamido-3-[2-(3-pyridyl)vinyl]-3-cephem-4-carboxylate (cis-trans mixture)(5.9 g), anisole (6 ml) and trifluoroacetic acid (20 ml) was stirred at ambient temperature for 30 minutes. The reaction mixture was added to di-iso-propylether (300 ml). The precipitate was collected by filtration, washed with di-iso-propylether to give 7-phenylacetamido-3-[2-(3-pyridyl)vinyl]-3-cephem-4-carboxylic acid trifluoroacetate (cis-trans mixture) (2.5 g).

WORKUP

后处理

filtrationThe precipitate was collected by filtration
washwashed with di-iso-propylether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7bfe06a365cf41dba6ef82a00d1086e2
来源数据集: uspto-grants-1987_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04639448
来源说明: uspto-grants-1987_01

反应 SMILES

[C:1]1([CH2:7][C:8]([NH:10][CH:11]2[C:42](=[O:43])[N:13]3[C:14]([C:26]([O:28]C(C4C=CC=CC=4)C4C=CC=CC=4)=[O:27])=[C:15]([CH:18]=[CH:19][C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(OC)C=CC=CC=1.[F:52][C:53]([F:58])([F:57])[C:54]([OH:56])=[O:55]>C(OC(C)C)(C)C>[F:52][C:53]([F:58])([F:57])[C:54]([OH:56])=[O:55].[C:1]1([CH2:7][C:8]([NH:10][CH:11]2[C:42](=[O:43])[N:13]3[C:14]([C:26]([OH:28])=[O:27])=[C:15]([CH:18]=[CH:19][C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1