Methane → 2-(beta-Hydroxypropyl)amino-6-(beta-hydroxypropyl)aminonitrobenzene
Reaction equation
C.Cl[C:3]1[CH:8]=[C:7]([NH:9][CH2:10][CH:11]([OH:13])[CH3:12])[C:6]([N+:14]([O-:16])=[O:15])=[C:5]([NH:17][CH2:18][CH:19]([OH:21])[CH3:20])[CH:4]=1.C(O)C.C(N(CC)CC)C>[Pd].C(O)=O>[OH:13][CH:11]([CH3:12])[CH2:10][NH:9][C:7]1[CH:8]=[CH:3][CH:4]=[C:5]([NH:17][CH2:18][CH:19]([OH:21])[CH3:20])[C:6]=1[N+:14]([O-:16])=[O:15]Participants
7
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Procedure
340 mg of palladium at a concentration of 10% on active charcoal are added to 0.07 mole (21.3 g) of 4-chloro-2-(β-hydroxypropyl)amino-6-(β-hydroxypropyl)aminonitrobenzene in 30 ml of 96° ethanol and 29.2 ml of triethylamine, after which 5.8 ml of formic acid are run in dropwise.
Sources & evidence
- ORD record
- ord-307eda3cdeb5446f830b85ccd30ab4a2
- Source dataset
- uspto-grants-1991_02
- Patent number
- US04992586
Reaction notes
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