反应详情

温度

20 °C

10.00 kg (43.6 mol) of methyl 3-(bromomethyl)benzoate and 5.21 kg (43.74 mol) of 4-hydroxybenzonitrile are dissolved in 100 litres of acetone and stirred with 8.4 kg (60.7 mol) of potassium carbonate in the presence of 0.1 kg of sodium iodide for about 4 h under reflux conditions. Then 35 litres of acetone are distilled off and 100 litres of water are added at reflux conditions. The reaction mixture is cooled to 20° C. and the crystallisation is completed by the addition of another 30 litres of water. The crystals formed are separated off, washed with 50 litres of water and dried in vacuo.

1. distillationThen 35 litres of acetone are distilled off
2. addition100 litres of water are added
3. temperatureat reflux conditions
4. customthe crystallisation
5. additionis completed by the addition of another 30 litres of water
6. customThe crystals formed
7. customare separated off
8. washwashed with 50 litres of water
9. customdried in vacuo