Methyl bromoacetate → HCID 22498599, compound

HRID 984472Notes

Reaction equation

HRID 984472 reaction equation
Br[CH2:2][C:3]([O:5][CH3:6])=[O:4].[NH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16].C(N(C(C)C)CC)(C)C>C(Cl)Cl>[C:3]([CH2:2][NH:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16])([O:5][CH3:6])=[O:4]

Participants

5

Reactant 3

HCID 60984Methyl bromoacetateHCID 81531DiisopropylethylamineHCID 821111-(3-Aminopropyl)-2-pyrrolidinone

Product 1

HCID 22498599HCID 22498599, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methyl bromoacetate (1.35 mL, 14.3 mmol) was added dropwise to a solution of 3-aminopropyl-2-pyrrolidinone (2.0 mL, 14.3 mmol) and diisopropylethylamine (2.7 mL) in CH2Cl2. The reaction was stirred for 12 hours and was then concentrated in vacuo, and carried forward without further purification.

Workup

  1. concentrationwas then concentrated in vacuo
  2. customcarried forward without further purification

Sources & evidence

ORD record
ord-435b55c3318248b5a337df20ddeccd8d
Source dataset
uspto-grants-2005_03
Patent number
US06867203B2

Reaction notes

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