Dimethylformamide → HCID 10297440, compound

HRID 984822Notes

Reaction equation

HRID 984822 reaction equation
[Br:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=2[N:7]=[C:6]1Cl.Cl.Cl.[NH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][NH:28][CH2:27]1.C(N(CC)CC)C.CN(C=O)C>CC(O)C>[NH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][N:28]([C:6]2[N:5]([CH2:4][C:3]3[CH:19]=[CH:20][CH:21]=[CH:22][C:2]=3[Br:1])[C:13]3[C:12](=[O:14])[N:11]([CH3:15])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=3[N:7]=2)[CH2:27]1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 598207Purine-2,6(1H,3H)-dione, 7-(2-bromobenzyl)-8-chloro-1,3-dimethyl-HCID 16211870Piperidin-3-amine dihydrochloride

Product 1

HCID 10297440HCID 10297440, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

7-(2-Bromobenzyl)-8-chloro-1,3-dimethyl-3,7-dihydropurine-2,6-dione (10A) (100 mg, 0.26 mmol) and 3-aminopiperidine dihydrochloride (226 mg, 1.31 mmol) were dissolved in 2-propanol (20 ml), triethylamine (0.109 ml, 0.78 mmol) and DMF (5 ml) and subjected to microwaves (method F, 130° C., 300 W) for ten hours. The solvents were evaporated and the crude product was purified by preparative HPLC, (method A1, Rt=7.52 min.) to give the title compound as a brown oil.

Workup

  1. customThe solvents were evaporated
  2. customthe crude product was purified by preparative HPLC, (method A1, Rt=7.52 min.)

Sources & evidence

ORD record
ord-73480627d094444aa1f55d55c052a18a
Source dataset
uspto-grants-2005_03
Patent number
US06869947B2

Reaction notes

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