反应详情

A 25 ml-flask was charged with 0.637 g of hydroquinone, 1 g of optically active 1-bromo-6-methyloctane, 0.667 g of anhydrous potassium carbonate and 4 ml of N,N-dimethylformamide, and reaction was carried out at 90° C. for 9.5 hours. After the reaction, insoluble substances were recovered by filtration and extracted with ether. The ether layer was washed with water and a saturated aqueous solution of sodium chloride and dried, and ether was removed by distillation under reduced pressure. The obtained crude product was purified by silica gel chromatography to obtain 0.32 g of optically active 4-(6'-methyloctyloxy)phenol.

1. customAfter the reaction, insoluble substances
2. filtrationwere recovered by filtration
3. extractionextracted with ether
4. washThe ether layer was washed with water
5. dry with materiala saturated aqueous solution of sodium chloride and dried
6. customether was removed by distillation under reduced pressure
7. customThe obtained crude product
8. customwas purified by silica gel chromatography