反应详情

After 15 minutes, 202 mg (0.50 mmol) of mevinolin are added and the reaction mixture is kept at −77° C. for 30 minutes. Then 171 mg (1.0 mmol) benzyl bromide are added. After 2 hours the reaction is let come to room temperature and poured onto 0.1 N aqueous HCl. The phases are separated and the aqueous phase is extracted twice with ethyl acetate. The organic phases are combined, washed with brine and dried over sodium sulfate. The solvent is evaporated and the crude product is purified by silica gel chromatography (diethyl ether/hexane 2/1) to afford the desired product as a colorless oil.

1. waitthe reaction mixture is kept at −77° C. for 30 minutes
2. waitAfter 2 hours the reaction is let come to room temperature
3. customThe phases are separated
4. extractionthe aqueous phase is extracted twice with ethyl acetate
5. washwashed with brine
6. dry with materialdried over sodium sulfate
7. customThe solvent is evaporated
8. customthe crude product is purified by silica gel chromatography (diethyl ether/hexane 2/1)