反应详情

144 mmol of triethylamine are added to a solution containing 96.4 mmol of 2-amino-5-methoxybenzenesulphonamide in 200 ml of tetrahydrofuran (THF), followed dropwise by a solution containing 135 mmol of 4-chlorobutanoic acid chloride in 30 ml of THF. After stirring overnight at room temperature, the THF is removed by evaporation and the residue is taken up in water. After extraction with ethyl acetate, the organic phase is washed and dried. After evaporation, the expected product is obtained in the form of an oil.

1. customthe THF is removed by evaporation
2. extractionAfter extraction with ethyl acetate
3. washthe organic phase is washed
4. customdried
5. customAfter evaporation