反应详情

To a solution of tert-butyloxycarbonyl-O-benzyl-D-serine methyl ester (BF8-EZ0-275) (5.0 g, 16 mmol) stirring in dichloromethane (40 mL) and anisole (1 mL) at 0° C. was added trifluoroacetic acid (10 mL). After 4 h at room temperature, a saturated aqueous solution of sodium bicarbonate was added and the resulting mixture extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over sodium sufate, and concentrated. The crude product was used in the next step without further purification.

1. extractionthe resulting mixture extracted with ethyl acetate
2. washThe combined organic extracts were washed with brine
3. dry with materialdried over sodium sufate
4. concentrationconcentrated
5. customThe crude product was used in the next step without further purification